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Commit edb67f95 authored by Sebastian Henz's avatar Sebastian Henz
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Update the documentation, closes #27.

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#' ECx-SyS
#'
#' The ECx-SyS model for modeling concentration-survival relationships with
#' hormesis.
#' ECx-SyS is a model for tri-phasic concentration-response relationships where
#' hormetic and subhormetic effects are observed at low concentrations. It
#' expands the Stress Addition Model (SAM) by introducing system stress (SyS)
#' which is negatively correlated with toxicant stress. See the publication for
#' details.
#'
#' It is advised to complete the curve down to zero for optimal prediction.
#' Therefore \code{survival_tox_observed} in the highest concentration should be
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......@@ -17,10 +17,11 @@
# along with this program. If not, see <https://www.gnu.org/licenses/>.
#' Predict the survival of a mixture of two toxicants
#' Predict the survival of binary toxicant mixtures
#'
#' Given the ECx-SyS models of two toxicants this method predicts the survival
#' of different mixtures.
#' The Multi-TOX model predicts the effects of binary toxicant mixtures taking
#' into account three-phasic concentration-response relationships. See the
#' publication for details.
#'
#' The predictions are symmetric, i.e. it does not matter which of the toxicant
#' models is 1 or 2 as long as the concentration arguments are supplied in the
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# stressaddition
This is the R implementation of the tri-phasic concentration-response model introduced in
[Liess, M., Henz, S. & Knillmann, S. Predicting low-concentration effects of pesticides. Sci Rep 9, 15248 (2019).](https://doi.org/10.1038/s41598-019-51645-4)
It allows modeling of ecotoxicological experiments where the response shows signs of a hormesis effect.
[Liess, M., Henz, S. & Knillmann, S. Predicting low-concentration effects of pesticides. Sci Rep 9, 15248 (2019)](https://doi.org/10.1038/s41598-019-51645-4). It allows modeling of ecotoxicological experiments where the response shows signs of a hormesis effect.
The EC<sub>x-SyS</sub> and Multi-TOX models from this package are also available as part of the [Indicate app](http://www.systemecology.eu/indicate) which offers a graphical user interface.
## Installation
Stressaddition is not on CRAN. You can install the most recent stable version from GitLab using the remotes package:
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......@@ -69,8 +69,11 @@ A list (of class ecxsys) containing many different objects of which
}
}
\description{
The ECx-SyS model for modeling concentration-survival relationships with
hormesis.
ECx-SyS is a model for tri-phasic concentration-response relationships where
hormetic and subhormetic effects are observed at low concentrations. It
expands the Stress Addition Model (SAM) by introducing system stress (SyS)
which is negatively correlated with toxicant stress. See the publication for
details.
}
\details{
It is advised to complete the curve down to zero for optimal prediction.
......
......@@ -2,7 +2,7 @@
% Please edit documentation in R/multi_tox.R
\name{multi_tox}
\alias{multi_tox}
\title{Predict the survival of a mixture of two toxicants}
\title{Predict the survival of binary toxicant mixtures}
\usage{
multi_tox(
model_a,
......@@ -34,8 +34,9 @@ A data frame with columns of the supplied concentrations and the
corresponding mixture survival and stresses.
}
\description{
Given the ECx-SyS models of two toxicants this method predicts the survival
of different mixtures.
The Multi-TOX model predicts the effects of binary toxicant mixtures taking
into account three-phasic concentration-response relationships. See the
publication for details.
}
\details{
The predictions are symmetric, i.e. it does not matter which of the toxicant
......
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